Professor and Vice Chair for Research in Radiology, School of Medicine
Professor of Biological Sciences, College of Arts and Science
Professor, MU Institute for Data Science and Informatics

NextGen Focus Area: Imaging (Translational Imaging and Alzheimer’s disease)

Ai-Ling Lin’s research on Alzheimer’s disease focuses on identifying effective pharmacological and nutritional interventions to prevent the disease in a mouse model carrying human APOE4 genes, the strongest genetic risk factor for developing Alzheimer’s. She also has applied artificial intelligence to identify markers that are highly predictive for Alzheimer’s disease development and progression and applied gut microbiome analyses to study gut-brain interaction underlying the disease. 

Precision Health Impact:

• Translational neuroimaging of brain vascular and metabolic function in aging, Alzheimer’s disease, stroke and traumatic brain injury.
• Precision interventions to protect the brain from aging, traumatic brain injury and Alzheimer’s disease.
• Artificial intelligence to predict Alzheimer's disease development and progression.

Publications:

• Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, et al. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. J Cereb Blood Flow Metab. 2013 Sep;33(9):1412–21. 
• Hoffman JD, Yanckello LM, Chlipala G, Hammond TC, McCulloch SD, Parikh I, et al. Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. PLoS One. 2019;14(8):e0221828. 
• Ma D, Wang AC, Parikh I, Green SJ, Hoffman JD, Chlipala G, et al. Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. Sci Rep. 2018 Apr 27;8(1):6670. 
• Lin AL, Fox PT, Hardies J, Duong TQ, Gao JH. Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8446–51. 
• Lin AL, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, et al. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease. J Cereb Blood Flow Metab. 2017 Jan;37(1):217–26. 

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Lin Brain Lab

Email: ai-ling.lin@health.missouri.edu
Department website: https://medicine.missouri.edu/faculty/ai-ling-lin-phd