Director, NextGen Precision Health Center for Reproductive Sciences
Vice Chair of Research, Department of Obstetrics, Gynecology and Women’s Health
Dr. R. Philip and Diane Acuff Endowed Professor, School of Medicine School of Medicine
NextGen Focus Area: Reproductive Health
Jae-Wook Jeong’s research focuses on understanding the molecular and cellular mechanisms that regulate uterine function and contribute to reproductive diseases, particularly endometriosis, infertility and endometrial cancer. His laboratory investigates steroid hormone signaling, endometrial receptivity, inflammation, fibrosis, epigenetic regulation and tumor progression to identify mechanisms underlying these disorders and develop new diagnostic and therapeutic strategies. His research program integrates human tissues and multi-omics approaches with genetically engineered mouse models and translational large-animal models. A major emphasis of his work is developing clinically relevant models and precision therapeutic approaches for endometriosis-associated infertility and pain, as well as metastatic and recurrent endometrial cancer.
Precision Health Impact:
- Identifying molecular mechanisms and biomarkers underlying endometriosis, endometriosis-associated infertility and endometrial cancer.
- Integrating genomic, epigenomic, transcriptomic and molecular approaches to understand disease development, progression and therapeutic response in gynecologic disorders.
- Developing innovative experimental and translational models, including genetically engineered mouse models, endometrial organoids and preclinical swine models, to study reproductive diseases and evaluate new therapies.
- Developing nonhormonal and precision therapeutic strategies for endometriosis, infertility and endometrial cancer, including targeted molecular therapies and nanotechnology-based approaches.
Publications:
Marquardt RM, Tran DN, Lessey BA, Rahman MS, Jeong JW. Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics. Endocr Rev. 2023 Nov 9;44(6):1074–95. doi:10.1210/endrev/bnad020 PubMed PMID: 37409951; PubMed Central PMCID: PMC10638603.
Tran DN, Hwang YJ, Kim KC, Li R, Marquardt RM, Chen C, et al. GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization. Nat Commun. 2025 Mar 4;16(1):2192. doi:10.1038/s41467-025-57173-2 PubMed PMID: 40038241; PubMed Central PMCID: PMC11880417.
Kim TH, Yoo JY, Choi KC, Shin JH, Leach RE, Fazleabas AT, et al. Loss of HDAC3 results in nonreceptive endometrium and female infertility. Sci Transl Med. 2019 Jan 9;11(474):eaaf7533. doi:10.1126/scitranslmed.aaf7533 PubMed PMID: 30626716; PubMed Central PMCID: PMC6650287.
Yoo JY, Kim TH, Shin JH, Marquardt RM, Müller U, Fazleabas AT, et al. Loss of MIG-6 results in endometrial progesterone resistance via ERBB2. Nat Commun. 2022 Mar 1;13(1):1101. doi:10.1038/s41467-022-28608-x PubMed PMID: 35232969; PubMed Central PMCID: PMC8888616.
Rahman MS, Park Y, Hosseinirad H, Shin JH, Jeong JW. The interplay between endometriosis and obesity. Trends Endocrinol Metab. 2025 Dec;36(12):1140–53. doi:10.1016/j.tem.2025.03.011 PubMed PMID: 40280861; PubMed Central PMCID: PMC12439108.
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Email: jeongjw@missouri.edu
Department website: https://medicine.missouri.edu/faculty/jae-wook-jeong-phd