Assistant Professor of Radiation Oncology, School of Medicine
Assistant Professor of Chemistry, College of Arts and Science
NextGen Focus Area: Precision Oncology
Dr. Khan’s primary research focus is understanding how cancer evades various treatments and uses this understanding to innovate precision oncology strategies to address the overarching challenge of therapeutic resistance. Dr Khan’s research group, Precision Oncology Lab, is particularly interested in developing novel molecular imaging tools and therapeutic interventions to address heterogeneity and metabolic reprogramming in cancer.
Precision Health Impact:
- Understanding the epigenetic basis of heterogeneity in head and neck cancer
- Biomarker discovery of therapeutic resistance in cancer
- Investigating radiation biology of novel radiotherapies for clinical translation
Publications:
Natarajan A, Khan S, Liang X, Nguyen H, Das N, Anders D, et al. Preclinical Evaluation of 89Zr-Panitumumab for Biology-Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2023 Jul 15;116(4):927–34.
Khan S, Shin JH, Ferri V, Cheng N, Noel JE, Kuo C, et al. High-resolution positron emission microscopy of patient-derived tumor organoids. Nat Commun. 2021 Oct 7;12(1):5883.
Khan S, Bassenne M, Wang J, Manjappa R, Melemenidis S, Breitkreutz DY, et al. Multicellular Spheroids as In Vitro Models of Oxygen Depletion During FLASH Irradiation. Int J Radiat Oncol Biol Phys. 2021 Jul 1;110(3):833–44.
Khan S, Kim S, Yang YP, Pratx G. High-resolution radioluminescence microscopy of FDG uptake in an engineered 3D tumor-stoma model. Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3400–7.
Khan S, Gupta A, Verma NC, Nandi CK. Time-Resolved Emission Reveals Ensemble of Emissive States as the Origin of Multicolor Fluorescence in Carbon Dots. Nano Lett. 2015 Dec 9;15(12):8300–5.
Google Scholar
PubMed
Lab website: https://medicine.missouri.edu/centers-institutes-labs/precision-oncology-lab
Email: syamantak.khan@health.missouri.edu
Department website: https://medicine.missouri.edu/faculty/syamantak-khan-phd