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Brian Clark, a professor of physiology at Ohio University, is driven by the idea that targeting aging itself could have a greater impact than curing any single disease. Working at the forefront of aging research, he aims to understand and intervene in the biological processes that underlie age-related physical decline. 

Clark’s work centers on the concept of “healthspan,” the period of time in which we can live independently and maintain a high quality of life. His work focuses on maintaining the strength, function, and vitality of those years by uncovering the mechanisms that drive age-related muscle loss, skeletal weakness, and neurological deterioration. “Ultimately, my goal with all of these approaches is to keep people out of the nursing home,” explains Clark. 

With an approach that examines both the neuromuscular and skeletal systems, Clark's research reveals that age-related weakness is not just a muscular problem. It’s also a neurological one, rooted in how effectively nerves communicate with muscles. By integrating these two essential aspects of physical health, his work offers a more complete picture of what it means to age well and remain independent. 

To Clark, one of the most intriguing aspects of aging is its variability. “You can have an 80-year-old at the biological age of a 70-year-old, or you could have a 70-year-old at the biological age of an 80-year-old,” Clark says. To better understand this diversity in the aging process, his research extends beyond physiology to the development of diagnostic tools to reveal the invisible aspects of aging. 

For instance, recognizing that traditional bone-density scans fail to capture the full picture of skeletal health, Clark and his collaborators developed a new vibration-based technology that measures bone stiffness and strength more directly. This innovation—commercialized by medical startup OsteoDx—gives clinicians a much clearer understanding of skeletal health and fracture risk. By refining these diagnostic tools, Clark hopes to detect weaknesses earlier and enable interventions before independence is lost.