Associate Professor of Surgery and Molecular Microbiology and Immunology; Adjunct Professor of Dermatology, School of Medicine
Associate Professor of Biological and Biomedical Engineering, College of Engineering
Adjunct Associate Professor of Animal Sciences, College of Agriculture, Food and Natural Resources

NextGen Focus Area: Cancer and Immunology

Adam Schrum’s research is focused on physiologic signaling networks and how they function in molecular and cellular immunity. One of his main goals is to increase the understanding of how T cells in the immune system decide whether to destroy or tolerate healthy, infected or cancerous tissue, with an eye toward applying lessons learned to the design of new immunotherapies. 

Precision Health Impact:

• Understanding how the immune system responds to cancer and infection.
• Investigating T-cell responses during development, infection, autoimmunity and cancer. 

Publications:

• Laffey KG, Stiles RJ, Ludescher MJ, Davis TR, Khwaja SS, Bram RJ, et al. Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2118529119.
• Holliday ZM, Earhart AP, Alnijoumi MM, Krvavac A, Allen LAH, Schrum AG. Non-Randomized Trial of Dornase Alfa for Acute Respiratory Distress Syndrome Secondary to Covid-19. Front Immunol. 2021;12:714833.
• Becher LRE, Nevala WK, Sutor SL, Abergel M, Hoffmann MM, Parks CA, et al. Public and private human T-cell clones respond differentially to HCMV antigen when boosted by CD3 copotentiation. Blood Adv. 2020 Nov 10;4(21):5343–56.
• Schrum AG, Neier SC, VanHook AM. Science Signaling Podcast for 2 August 2016: Patient-specific protein complexes. Sci Signal. 2016 Aug 2;9(439):c17.
• Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, et al. The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network. Sci Immunol. 2019 Feb 15;4(32):eaal2201.

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     PubMed

     ResearchGate

Email: schruma@health.missouri.edu
Department website: https://medicine.missouri.edu/faculty/adam-g-schrum-phd