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Alejandro Chade, MD

Alejandro Chade, PhD

Professor of Medical Pharmacology and Physiology, School of Medicine

NextGen Focus Area: Cardiovascular and Metabolic Disorders

Alejandro Chade utilizes translational swine models of chronic renovascular disease (RVD), hypertension, chronic kidney disease (CKD) and early-stage cardiac failure that have been developed and characterized throughout his research career. His unique physiological imaging techniques use multidetector computerized tomography to noninvasively measure renal regional volume, total renal blood flow, glomerular filtration rate, tubular dynamics and endothelial function; echocardiography to investigate the impact on cardiac function and structure; and high-resolution microcomputed tomography to study the 3D architecture of the renal and cardiac microcirculation in situ. These integrated techniques allow Dr. Chade to serially follow the time course of the deterioration of the renal and cardiac function with previously unavailable accuracy. Current efforts in his laboratory also are devoted to the discovery and development of novel drug-delivery-based therapeutic strategies to protect renal and cardiac microcirculation in a targeted fashion, offset inflammation at a molecular level and recover renal and cardiac function in RVD and CKD in a manner that potentially could be applied to humans. Understanding the mechanisms of disease, identifying markers and using targeted interventions could have important ramifications for pinpointing those patients who will benefit from treatments for these diseases. 

Precision Health Impact:

  • Elucidating the mechanisms of renal and cardiac injury in chronic kidney disease. 
  • Elucidation of novel mechanisms of cross-talk between the diseased kidneys and the heart in the development of cardiac failure. 
  • Identification of new targets in the kidneys and in the heart to guide the development of novel molecularly targeted therapies. 


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