Assistant Professor of Animal Sciences, College of Agriculture, Food and Natural Resources
Assistant Professor of Obstetrics, Gynecology and Women’s Health, School of Medicine

NextGen Focus Area: Female Reproductive Biology, Tissue Regeneration, Stem Cell Biology

Amanda Patterson studies uterine function in health and disease in women and cattle. Specifically, she investigates the molecular and cellular mechanisms of endometrial regeneration and the consequences of inappropriate regeneration and uterine infection on subsequent function and fertility. She also studies the pathogenesis of uterine fibroids and adenomyosis, gynecological diseases, that may arise as a consequence of dysregulated regenerative mechanisms.

Precision Health Impact:

• Investigation of the normal mechanisms of menstrual and postpartum endometrial regeneration to advance our understanding of women’s reproductive health
• Elucidation of the pathobiology of uterine fibroids and adenomyosis, highly prevalent gynecological disease that often result in hysterectomy

Publications:

Sellmer Ramos I, Caldeira MO, Patterson AL, Lucy MC. Uterine glands originate from islands of FOXA2-positive luminal epithelium cells that differentiate de novo and invade uterine stroma†. Biol Reprod. 2024 Jan 13;110(1):1–4.

Lenis YY, George JW, Lind S, Balboula A, Teixeira JM, Patterson AL. The Effects of Periostin Expression on Fibroid-Like Transition of Myometrial Cells. Reprod Sci. 2023 May;30(5):1616–24.

Spooner-Harris M, Kerns K, Zigo M, Sutovsky P, Balboula A, Patterson AL. A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling. Cell Tissue Res. 2023 Feb;391(2):393–408.

Spooner MK, Lenis YY, Watson R, Jaimes D, Patterson AL. The role of stem cells in uterine involution. Reproduction. 2021 Mar;161(3):R61–77.

Patterson AL, George JW, Chatterjee A, Carpenter TJ, Wolfrum E, Chesla DW, et al. Putative human myometrial and fibroid stem-like cells have mesenchymal stem cell and endometrial stromal cell properties. Hum Reprod. 2020 Jan 1;35(1):44–57.

Google Scholar

PubMed

Patterson Lab Website

Email: pattersonama@missouri.edu
Department website: https://cafnr.missouri.edu/directory/amanda-patterson