Assistant Professor of Obstetrics, Gynecology and Women’s Health, School of Medicine
Assistant Research Professor, College of Agriculture, Food and Natural Resources
NextGen Focus Area: Reproductive Health
Andrew Kelleher's long-term research goal is to define the critical physiological and genetic pathways that regulate uterine development, function and regeneration for the diagnosis, treatment and prevention of infertility and disease in women. To this end, his research utilizes mouse genetic models, endometrial organoid culture (human and mouse) and next-generation sequencing methods to comprehensively determine physiological and molecular aspects of uterine function and disease.
Precision Health Impact:
- Understanding the mechanisms controlling uterine epithelial development, function and regeneration.
- Investigating the role of uterine glands in fertility and endometrial disease.
- Fitzgerald HC, Kelleher AM, Ranjit C, Schust DJ, Spencer TE. Basolateral secretions of human endometrial epithelial organoids impact stromal cell decidualization. Mol Hum Reprod. 2023 Apr 3;29(4):gaad007.
- Kelleher AM, Setlem R, Dantzer F, DeMayo FJ, Lydon JP, Kraus WL. Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2109252118.
- Dickson MJ, Oh Y, Gruzdev A, Li R, Balaguer N, Kelleher AM, et al. Inserting Cre recombinase into the Prolactin 8a2 gene for decidua-specific recombination in mice. Genesis. 2022 May;60(4–5):e23473.
- Kelleher AM, Allen CC, Davis DJ, Spencer TE. Prss29 Cre recombinase mice are useful to study adult uterine gland function. Genesis. 2022 Dec;60(10–12):e23493.
- Kelleher AM, Milano-Foster J, Behura SK, Spencer TE. Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success. Nat Commun. 2018 Jun 22;9(1):2435.
Department website: https://cafnr.missouri.edu/person/andrew-kelleher/