Associate Professor of Surgery and Molecular Microbiology and Immunology, School of Medicine
NextGen Focus Area: Cancer and Immunology (Inflammation and Infectious Diseases)
Emma Teixeiro conducts research on the lymphocytes of the immune system that fight against infection and cancer. Her main focus involves T cells that become effective at clearing pathogens (viruses such as influenza or SARS-CoV2 and bacteria) and tumor cells and providing long-term protection (immunological memory). Her goal is to improve therapies for infection and cancer (vaccines and T-cell-based tumor immunotherapies).
Precision Health Impact:
- Investigating how T-cell lymphocytes provide long-term protection against infection and cancer.
- Applying novel discoveries in T-cell biology to improve vaccines against influenza and other infectious diseases and tumor immunotherapies.
- Understanding how T cells contribute to transplant rejection.
Publications:
- Guan Y, Kraus SG, Quaney MJ, Daniels MA, Mitchem JB, Teixeiro E. FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer. Front Oncol. 2020;10:586.
- Daniels MA, Luera D, Teixeiro E. NFκB signaling in T cell memory. Front Immunol. 2023;14:1129191.
- Quaney MJ, Pritzl CJ, Luera D, Newth RJ, Knudson KM, Saxena V, et al. STING controls T cell memory fitness during infection through T cell-intrinsic and IDO-dependent mechanisms. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2205049120.
- Huseby ES, Teixeiro E. The perception and response of T cells to a changing environment are based on the law of initial value. Sci Signal. 2022 May 31;15(736):eabj9842.
- Smyth DS, Trujillo M, Gregory DA, Cheung K, Gao A, Graham M, et al. Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater. Nat Commun. 2022 Feb 3;13(1):635.
Google Scholar
PubMed
ResearchGate
Email: teixeiropernase@health.missouri.edu
Department website: https://medicine.missouri.edu/faculty/emma-teixeiro-pernas-phd