Assistant Professor of Obstetrics, Gynecology and Women’s Health, School of Medicine
NextGen Focus Area: Reproductive Health
Tae Hoon Kim is using novel mouse animal models and noninvasive imaging to investigate the molecular mechanisms regulating normal uterine physiology and molecular causes of uterine disease including endometriosis, adenomyosis and endometrial cancer. He has examined several signal transduction pathways that play pivotal roles in women’s disease and uterine biology. For example, Dr. Kim found several genes related to women’s diseases and uterine biology by studying mice that had the gene knocked out in one allele in uterine cells.
Precision Health Impact:
- Understanding the etiology and progression of women’s disease and uterine biology.
- Developing precision medicine in treating women’s disease.
- Developing noninvasive imaging for women’s disease and uterine biology.
- Marquardt RM, Nafiujjaman M, Kim TH, Chung SJ, Hadrick K, Kim T, et al. A Mouse Model of Endometriosis with Nanoparticle Labeling for In Vivo Photoacoustic Imaging. Reprod Sci. 2022 Oct;29(10):2947–59.
- Kim TH, Bae N, Kim T, Hsu AL, Hunter MI, Shin JH, et al. Leptin Stimulates Endometriosis Development in Mouse Models. Biomedicines. 2022 Sep 1;10(9):2160.
- Kim TH, Yoo JY, Choi KC, Shin JH, Leach RE, Fazleabas AT, et al. Loss of HDAC3 results in nonreceptive endometrium and female infertility. Sci Transl Med. 2019 Jan 9;11(474):eaaf7533.
- Yoo JY, Kim TH, Shin JH, Marquardt RM, Müller U, Fazleabas AT, et al. Loss of MIG-6 results in endometrial progesterone resistance via ERBB2. Nat Commun. 2022 Mar 1;13(1):1101.
- Jeong O, Broaddus RR, Lessey BA, Risinger JI, Hunter MI, Kim TH. MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer. Int J Mol Sci. 2022 Nov 23;23(23):14596.
Department website: https://medicine.missouri.edu/faculty/tae-hoon-kim-phd