Associate Professor of Obstetrics, Gynecology and Women’s Health, School of Medicine
NextGen Focus Area: Reproductive Health
Wipawee Winuthayanon's research involves multiple types of cells in the female reproductive tract that work in concert to provide an optimal microenvironment for gametes (eggs and sperm) and embryos to establish a successful pregnancy. Her lab studies how ovarian steroid hormones (estrogen and progesterone) affect fertility during sperm migration, fertilization, embryo development and embryo transport within the female reproductive tract. Dr. Winuthayanon's research uses genetically engineered mouse models to dissect the molecular mechanisms and functional requirement of estrogen and progesterone signals through their classical nuclear receptors (estrogen receptor ESR1 and progesterone receptor PGR) during early pregnancy. Her research aims to provide fundamental knowledge in reproductive biology during early pregnancy, potential contraceptive targets for both men and women and therapeutic approaches for infertility in humans.
Precision Health Impact:
- Understanding the impact of estrogen and progesterone in the fallopian tube during pregnancy establishment.
- Developing novel nonhormonal contraceptive methods for both men and women.
Publications:
- Anamthathmakula P, Erickson JA, Winuthayanon W. Blocking serine protease activity prevents semenogelin degradation leading to hyperviscous semen in humans. Biol Reprod. 2022 May 17;106(5):879–87.
- McGlade EA, Herrera GG, Stephens KK, Olsen SLW, Winuthayanon S, Guner J, et al. Cell-type specific analysis of physiological action of estrogen in mouse oviducts. FASEB J. 2021 May;35(5):e21563.
- Harris EA, Stephens KK, Winuthayanon W. Extracellular Vesicles and the Oviduct Function. Int J Mol Sci. 2020 Nov 5;21(21):8280.
- McGlade EA, Miyamoto A, Winuthayanon W. Progesterone and Inflammatory Response in the Oviduct during Physiological and Pathological Conditions. Cells. 2022 Mar 23;11(7):1075.
- Barton BE, Rock JK, Willie AM, Harris EA, Finnerty RM, Herrera GG, et al. Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice†. Biol Reprod. 2020 Aug 4;103(2):400–10.
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Dr. Winuthayanon's Lab
Email: w.winuthayanon@health.missouri.edu
Department website: https://medicine.missouri.edu/faculty/wipawee-winuthayanon-bsn-phd