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NextGen Discovery Series – Dec. 13, 2022


The NextGen Precision Health Discovery Series provides learning opportunities for UM System faculty and staff across disciplines, the statewide community and our other partners to learn about the scope of precision health research and identify potential collaborative opportunities. The series consists of monthly lectures geared toward a broad multidisciplinary audience so all can participate and appreciate the spectrum of precision health efforts. 

Information about this talk, including continuing education, is available below.

For questions about this event or any others in the Discovery Series, please reach out to Veronica Lemme at


The Data Science Renaissance in Precision Health: Balancing the Risks with the Potential Rewards

Speaker: Dr. Robert Paul, Director, Missouri Institute of Mental Health

Curator’s Distinguished Professor, Department of Psychological Sciences, University of Missouri, St. Louis

Date: Dec. 13, 2022, noon-1 p.m.




Machine learning applications in clinical neurosciences have emerged as a powerful, yet controversial approach to achieving highly personalized health care. Studies conducted in the fields of oncology, cardiology and other select disciplines provide foundational support for the utility of machine learning to facilitate the discovery of novel disease mechanisms, targets for therapeutic interventions and predictive models of individual outcomes. By comparison, the application of machine learning in clinical neuroscience has moved at a glacial pace. This presentation described the potential for machine learning to resolve longstanding knowledge gaps related to the most vexing neurologic and psychiatric conditions, as well as key challenges and methodologic/interpretative risks and recommendations for best practices. Outcomes from studies using ensemble machine learning were emphasized.


About the SpeakerRobert Paul

Dr. Paul’s research program is focused on mechanisms of brain dysfunction in health conditions that primarily impact brain structures located deep beneath the surface of the cerebral cortex. Dr. Paul’s research team has developed specific expertise in human immune deficiency syndrome (HIV), subcortical stroke and early life trauma as three conditions that impact the integrity of deep brain structures, including the white matter, basal ganglia and limbic structures. Neuropsychological methods and neuroimaging techniques are the primary research methods applied by Dr. Paul’s team to define behavioral and anatomical signatures of brain dysfunction in these conditions. Dr. Paul has a special interest in the application of these methods in resource-limited environments, and he has active research programs in South Africa, Africa, Thailand, Vietnam and Cambodia. He is a member of the HIV Cure Consortium, and he works closely with collaborators at the University of California San Francisco, Brown University, Yale University and Washington University.


Continuing Professional Education Credit

Successful Completion of this activity, which includes participating in the educational offering, participating in the evaluation process and completing the verification of attendance, enables the learner to satisfy the requirements for continuing education.

Nursing Contact Hours

University of Missouri Sinclair School of Nursing is approved as a provider of nursing continuing professional development by the Midwest Multistate Division, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation (ANCC). 

1.0 contact hour may be awarded.


The University of Missouri-Columbia School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

The University of Missouri-Columbia School of Medicine designates this live educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should only claim the credit commensurate with the extent of their participation in the activity.

Financial Relationships

Current ACCME and Midwest Multistate Division, ANCC rules state that participants in continuing education activities should be made aware of any relevant affiliation or financial interest in the previous 24 months that may affect the planning of an educational activity or a speaker’s presentation(s). Each planning committee member and speaker has been requested to complete a financial relationship reporting form for the NextGen Precision Health Discovery Series. No planning committee member or speaker has a relevant financial interest.