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"Molecular Disruptions at the Node of Ranvier: Mechanistic Insights into Charcot-Marie-Tooth Disease"

Speaker:
Kathryn Moss, PhD
Assistant Professor of Physical Medicine and Rehabilitation
School of Medicine, University of Missouri

Date: Monday, October 13, 2025, 4 p.m.

Location:
Roy Blunt NextGen Precision Health Building
Atkins Family Seminar Room

 Register Here

*Zoom option available

Description

This seminar will present new insights into how altered dosage of the most common Charcot-Marie-Tooth (CMT) gene, PMP22, disrupts the molecular architecture of peripheral myelin. I will focus on emerging data revealing striking defects at the Node of Ranvier in mouse models, a critical site for nerve conduction. These findings suggest a novel mechanism contributing to CMT pathogenesis and led us to a working model for how PMP22 imbalance drives disease. I will preview ongoing work on LAMP1 and discuss potential links between CMT and membrane fragility, broadening the mechanistic framework of peripheral neuropathies and pointing toward new therapeutic strategies.

Speaker Bio

Dr. Kathryn Moss is an Assistant Professor of Physical Medicine and Rehabilitation at the University of Missouri and a faculty member of the NextGen Precision Health initiative. Her laboratory investigates how the myelin protein PMP22 organizes peripheral nerve architecture and how its disruption drives Charcot-Marie-Tooth disease (CMT) and related neuropathies. By integrating advanced imaging with mouse models, cell systems, and patient-derived samples, her team is defining fundamental disease mechanisms and working to translate them toward durable therapeutic strategies. Dr. Moss has received national recognition for her work, including NIH career transition funding, leadership roles in the Peripheral Nerve Society, and multiple awards for advancing CMT research.

About the Neuroscience Seminar Series

The goal of the NextGen Precision Health Neuroscience Science Seminar is to highlight transdisciplinary precision research taking place in the field, provide opportunities for collaboration among researchers to build their own research efforts and promote clinical/researcher activity across the University of Missouri System and our partners.

For questions about this event, please reach out to Mackenzie Lynch at lynchmm@health.missouri.edu.