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NextGen Cardiovascular, Muscle, & Metabolism Science Seminar - Nov. 14, 2022


For questions about this event, please reach out to Veronica Lemme


"Cross-talk Between the Neuroendocrine and Autonomic Nervous Systems in the Regulation of Blood Pressure"

Presented by: De-Pei Li, MD, Associate Professor, MU School of Medicine

Date: Monday, Nov. 14, 2022, noon-1 p.m.




Hypertension is associated with elevated sympathetic nerve activity and activation of neuroendocrine neurons. We found recently that the neuroendocrine neurons — CRH neurons in the hypothalamus — link the neuroendocrine and sympathetic nervous systems. Suppression of CRH neurons decreased sympathetic outflow in hypertension. Thus, activation of CRH neuroendocrine neurons is required for elevated sympathetic nerve activity in hypertension.

Speak BioDe-Pei Li

Dr. De-Pei Li graduated from Hebei Medicine university in China in 1993. Dr. Li received his postdoc training in the research field of cardiovascular neurophysiology, with a focus on hypothalamic mechanisms involved in the elevated sympathetic nerve activity in hypertension. Dr. Li’s research focus is on understanding of neural mechanisms and identifying novel targets involved in the regulation of sympathetic outflow in hypertension. He has published 80 papers in scientific journals. Dr. Li’s research activity has been supported by the NIH R01 grants. He has served as a journal reviewer in the student section to review NIH and DOD grant applications. His research team recently found an interesting interaction between neuroendocrine and autonomic nervous systems and identified the role of this interaction in the regulation of blood pressure.