The goal of the NextGen Precision Health & Ellis Fischel Cancer Center Science Seminar is to highlight transdisciplinary precision research taking place in the cancer field, provide opportunities for collaboration among researchers to build their own research efforts and promote clinical/researcher activity across the University of Missouri System and our partners.

For questions about this event, please reach out to Mackenzie Lynch.

Genesis of a New Medical Modality: ‘Nano-Ayurvedic Medicine’ - Preclinical and Clinical Investigations

Speaker: Kattesh Katti, Ph.D., M.Sc.Ed., D.Sc., FRSC, FNAI
Director of Institute of Green Nanotechnology, Director of University of Missouri Cancer Nanotechnology Platform, Professor, Margaret Proctor Mulligan Professorship in Medical Research, Curators’ Distinguished Professor of Radiology & Physics, Dept. of Radiology, and Dept. of Medical Pharmacology & Physiology, University of Missouri-Columbia

Date: September 19, 2024, 4:30-5:30 p.m.

Location: Roy Blunt NextGen Precision Health Building, Atkins Family Seminar Room

*Zoom option available

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Description

In this presentation, Dr. Katti will provide credible scientific rationale to phytochemical-based herbal Ayurvedic medicine—paving the way for the discovery of a new Precision Medicine modality referred to as ‘Nano-Ayurvedic Medicine’. This lecture will discuss how Green Nanotechnology, through radiochemical and nuclear analytical tools, has resulted in the   development of reproducible formulations of herbal and classical Ayurvedic medicines thus providing a pathway for clinical trials for internal/external validity, to allow the safety and efficacy of specific herbal medicines in a more accurate and scientifically verifiable way. Katti’s lecture will also discuss details on how green nanotechnology can be used to develop small-molecule phytochemical(s)-functionalized gold nanoparticles to simultaneously achieve: (i) Inhibition of NF-kB activation; (ii) Targeting TAM; and (iii) Inhibition of TNF-α induced p65 phosphorylation; and concomitant immunomodulatory therapeutic action. Discussions will include preclinical and clinical investigations with particular emphasis on therapeutic strategies: (1) clearing macrophages and inhibiting the activation of TAMs, (2) reprogramming of pro-tumor M2‑like TAMs into the M1‑like anti-tumor phenotypes and (3) targeting TAMs complementing anti-angiogenic therapy.

About the Speaker

Globally recognized as the ‘Father of Green Nanotechnology’, Professor Kattesh V. Katti, MSc.Ed, PhD, DSc, FRSC, FNAI, Curators’ Distinguished Professor of Radiology, Director, Institute of Green Nanotechnology, within the Medical School, University of Missouri, Columbia, USA—is  internationally renowned as a leader in the interconnecting fields of—chemistry, Materials science, radiopharmaceutical sciences, nanotechnology/green nanotechnology and nanomedicine—for biomedical applications, specifically for molecular imaging and therapy of living subjects. Dr. Katti is a pioneer in the field of Nano-Ayurvedic Medicine—a new medical modality which he has discovered by the application of Nuclear Analytical, Radiochemical techniques and Green Nanotechnology to Ayurvedic-Holistic Medicine. In 2023, the US Patents and Trademarks office has granted the first ever US patent on Dr. Katti’s discovery of ‘Nano-Ayurvedic Medicine’ Several cancer therapy products and antibiotics, discovered by Dr. Katti, are currently used in treating human patients.