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NextGen Precision Health Neuroscience Seminar – Dec. 4, 2023

The goal of the NextGen Precision Health & Neuroscience Science Seminar is to highlight transdisciplinary precision research taking place in the field, provide opportunities for collaboration among researchers to build their own research efforts and promote clinical/researcher activity across the University of Missouri System and our partners.

For questions about this event, please reach out to Veronica Lemme at

"Developing Preclinical Swine Models to Study Neurodegenerative Diseases Using Genome Editing Technology"

Presented by: Kiho Lee, Ph.D., Associate Professor, Animal Research Center, College of Agriculture, Food & Natural Resources, University of Missouri

Date: Dec. 4, 2023, 4-5 p.m.

Location: Tom and Linda Atkins Family Seminar Room, Roy Blunt NextGen Precision Health Building

*Zoom option available

Register Here



Swine models can closely recapitulate clinical signs and symptoms, serving as an ideal preclinical model. The introduction of genetic information linked to human diseases into the swine genome allows the animal model to mirror clinical conditions. However, as a large animal species, introducing targeted genetic modifications into the swine genome comes with unique technical challenges. This seminar will illustrate the technical advancements that are critical to the successful establishment of genetically engineered swine models that reflect human conditions and will discuss swine models that have been developed to study neurodegenerative diseases such as Alzheimer’s disease. 

Speaker BioKiho Lee

Kiho Lee graduated from Seoul National University with a bachelor’s degree in animal sciences. He received his M.S. and Ph.D. from Purdue University, and postdoctoral training from the University of Missouri. While at MU, he generated immune-deficient pigs that could support growth and proliferation of human induced pluripotent stem cells. He is currently an associate professor in the Division of Animal Sciences at the University of Missouri. Dr. Lee’s lab currently focuses on designing genetically engineered large animal models for agriculture and biomedicine. One of the current models involve pig models reflecting clinical phenotype of Alzheimer’s diseases.