The goal of the NextGen Precision Health Neuroscience Science Seminar is to highlight transdisciplinary precision research taking place in the field, provide opportunities for collaboration among researchers to build their own research efforts and promote clinical/researcher activity across the University of Missouri System and our partners.

For questions about this event, please reach out to Mackenzie Lynch at lynchmm@health.missouri.edu.

“RNA Regulation of Membrane Trafficking and Secretion in Disease”

Presented by: 
Curtis Nutter, PhD
Assistant Professor of Biochemistry, School of Medicine

Date: May 5, 2025, 4-5 p.m.

Location: Roy Blunt NextGen Precision Health Building/Atkins Family Seminar Room

*Zoom option available 

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Speaker Bio

Co/post-transcriptional regulation of gene expression by alternative RNA processing is a highly regulated and complex process that exponentially increases the repertoire and dynamic control of gene products. Disrupted RNA processing is implicated in many human diseases, in particular neurological disorders. Alternative RNA processing is regulated by developmental and tissue specific RNA binding proteins (RBPs) which influence core RNA processing machinery. My group studies these regulatory interactions involved in co/post-transcriptional control of neurological development and cell membrane transport/secretion. We characterize these mechanisms using cutting edge RNA sequencing technology, single-molecule RNA detection, mass-spectroscopy, and CRISPR techniques to address our hypotheses in primary cell lines, patient samples, and animal model systems. This work will advance development of novel clinically relevant biomarkers and therapeutic paradigms for rare genetic and neurological disorders.