The goal of the NextGen Precision Health & Ellis Fischel Cancer Center Science Seminar is to highlight transdisciplinary precision research taking place in the cancer field, provide opportunities for collaboration among researchers to build their own research efforts and promote clinical/researcher activity across the University of Missouri System and our partners.

For questions about this event, please reach out to Mackenzie Lynch.

"Targeting the Tumor Microenvironment of Pancreatic Cancer to Improve Response to Therapy"

Speaker: David G. DeNardo, PhD, Professor; Section Co-Director Molecular Oncology, Washington University School of Medicine, St. Louis

Date: October 17, 2024, 4:30-5:30 p.m.

Location: Roy Blunt NextGen Precision Health Building, Atkins Family Seminar Room

Description

Dr. DeNardo will discuss the barriers to therapy induced by the tumor microenvironment and preclinical and clinical studies using therapeutic approaches to overcome the TME.

About the Speaker

The goal of Dr. DeNardo’s research program is to investigate how the tumor microenvironment regulates responses to therapy in cancer. Dr. DeNardo got his PhD from Baylor College of Medicine in Cell Biology where he studies nuclear hormone receptor signaling.  As a postdoctoral fellow at the University of California, San Francisco, with Dr. Lisa Coussens he studied how adaptive immune responses regulate macrophages in tumors. In 2011 he joined the faculty at Washington University, School of Medicine, in St. Louis (WUSM) and become a member of the Siteman Cancer Center. Over the last fourteen years his group has focused on three areas: 1) understanding the role of fibrosis in tumor immunity, 2) therapeutically reprograming myeloid and dendritic cell responses to improve response to therapy and 3) understanding the impact of myeloid cell heterogeneity’s impact on function.   Dr. DeNardo is the co-leader of Siteman Cancer Center’s Tumor Immunology Program, Leader of the Tumor Microenvironment Section within the Division of Oncology, and Leader of WUSMs SPORE in pancreatic cancer. His lab currently focuses on pancreatic, lung and breast cancers and there interaction with the immune system and stromal enviorment.